Project Details
Projekt
Engineering CAR-T cells against neuroblastoma with synthetic notch receptors to increase tumor-specificity and endogenous immune activation (A06)
Subject Area
Immunology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 452881907
Targeting solid cancers like neuroblastoma with CAR-T cells remains challenging. CRISPR/Cas9 gene-editing technology makes elaborate lymphocyte engineering possible, but the risk rises that the recipient’s immune system rejects CAR-T cells the more elaborately they are engineered. Furthermore, the large numbers of starting cells often required can be difficult to obtain for pediatric patients and the time required to manufacture autologous CAR-T cell products is often too long to fight fast growing tumors. In this project, we will develop a highly tumor-specific, allogenic CAR-T cell product armored with cytokines to modulate the neuroblastoma tumor microenvironment and prevent tumor escape.
DFG Programme
CRC/Transregios
Applicant Institution
Technische Universität München (TUM)
Project Head
Professorin Dr. Annette Künkele-Langer
