Removal of the acidosis-dependent immune evasion mechanism of the malignant melanoma using pH modulating nanocarrier (B16*)

• Subject Area: Immunology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213555243

The goal of B16N is to change the metabolic status of the tumor microenvironment using pH-modulating nanocarriers. Aggressive, fast-growing tumors are characterized by an acidic microenvironment that pro-motes the differentiation of a non-inflammatory macrophage subtype. The increase of the pH value will be imaged using PET and the resulting effects on tumor infiltrating immune cells will be investigated using PET and OMICS analyses. Furthermore, tumor spheroids generated from human tumor biopsies are used to translate pH modulation and its effects on immune cell infiltrates to human tumors.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1066: Nano-Dimensional Polymer Therapeutics for Tumour Therapy
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Dr. Toszka Bohn; Professor Dr. Matthias Miederer, Ph.D.; Professorin Dr. Tanja Weil