Mechanisms of locally controlled JARID1B histone demethylase activity (A12)

• Subject Area: Biochemistry ; Structural Biology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424228829

Pöpsel aims to unravel JARID1B-mediated regulation of cell state transitions by an integrative biochemical and structural approach. He will (1) structurally define substrate engagement and demethylase activity in the chromatin context using cryo-electron microscopy of JARID1B with an emphasis on its interactions with nucleosomes and (2) identify biochemical determinants of JARID1B interaction dynamics focusing on the mechanism of the recognition of the tumour suppressor retinoblastoma protein, a key mediator of JARID1B function. He will extend this expertise to other projects within the CRC.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1430: Molecular Mechanisms of Cell State Transitions
• Applicant Institution: Universität Duisburg-Essen
• Project Head: Dr. Simon Pöpsel