Project Details
Projekt
Steatosis associated soiI factors of the liver metastatic niche (B11)
Subject Area
Hematology, Oncology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 429280966
The liver is a highly metastasis-permissive organ. The molecular mechanisms that render the liver such hospitable to disseminated tumor cells are widely elusive. We found that the attractiveness of the liver for metastasizing cancer cells is further enhanced by hepatic steatosis. The general goal of this project is to identify the molecular mechanisms that promote the colonization of disseminated cancer cells into the steatotic hepatic environment and to validate their potential as novel therapeutic targets. We will also test whether identified factors affect colonization of non-steatotic liver tissue as well as other metastatic niches, where they may be less abundant but still effective.
DFG Programme
CRC/Transregios
Subproject of
TRR 305:
Striking a moving target: From mechanisms of metastatic colonization to novel systemic therapies
Applicant Institution
Universität Regensburg
Project Head
Professor Dr. Claus Hellerbrand
