Organ defense during metastatic colonization by shielding macrophages (B03)

• Subject Area: Hematology, Oncology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 429280966

We have previously identified a conserved “danger containing” Trem2+ macrophage population, which emerged from data of single cell sequencing and preclinical models across various states of inflammation and cancer. These Trem2+ macrophages display a unique immune-regulatory gene expression profile and seem to be able to contain damage and prevent inflammation and local immunity by physical segregation. In project B03, we aim to study the role and origin of these cells during metastatic organ colonization using state of the art imaging, fate-mapping, spatial transcriptomics and single cell RNA sequencing to validate their potential as targets for therapeutic intervention during metastatic colonization.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 305: Striking a moving target: From mechanisms of metastatic colonization to novel systemic therapies
• Applicant Institution: Universität Regensburg
• Project Heads: Professor Dr. Gerhard Krönke; Professor Dr. Tobias Pukrop