Collective dynamics of ion channels: statistical modeling and analysis (B04)

• Subject Area: Mathematics ; Statistical Physics, Nonlinear Dynamics, Complex Systems, Soft and Fluid Matter, Biological Physics
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 432680300

The goal of this project is to provide a fundamental understanding of the collective behavior of multiple ion channels in lipid membranes. By combining voltage-clamp experiments and super-resolution microscopy on connexons with statistical analysis and modeling, we will address whether multiple channels act cooperatively or disruptively, and estimate the number of reconstituted channels. The results will be of great importance to unravel the mechanism and regulation of signal transmission between cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1456: Mathematics of Experiment: The challenge of indirect measurements in the natural sciences
• Applicant Institution: Georg-August-Universität Göttingen
• Project Heads: Dr. Housen Li; Professorin Dr. Claudia Steinem