Ensemble inference – new sampling algorithms and applications in structural biology
(B02)
Subject Area
Biophysics
Mathematics
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 432680300
How should we create a microscopic physical model for biomolecular structure ensembles so as to reproduce observed bulk averages? Driven by this question, our project aims to develop, analyze and tune algorithms for Bayesian inference of ensemble models for protein structures. The envisioned developments allow us to infer protein ensembles from nuclear magnetic resonance data and thereby gain a better understanding of the formation of protein-protein complexes.
DFG Programme
Collaborative Research Centres
