Next Generation Connectomics: Laminar and Spectral Specificity

• Applicants: Professor Klaus Scheffler, Ph.D., since 6/2024; Professor Dr. Markus Siegel
• Subject Area: Experimental and Theoretical Network Neuroscience ; Cognitive, Systems and Behavioural Neurobiology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 455175312

The human brain is a highly complex, but structured network. Interactions between brain regions are layer-specific and entail neuronal oscillations in different frequency ranges. Yet, current large-scale connectomics largely ignore these features and typically characterize brain networks as uniform connections between monolithic nodes. The central goal of this project is to overcome this limitation. We will develop and employ novel simultaneous ultra-high field MRI (9.4 T) and EEG to map the laminar connectome of the human brain and to link it to frequency specific neuronal activity. Based on this next-generation connectome, we aim to identify unifying computational principles of corticocortical interactions. In particular, we want to test the hypothesis that interactions between brain regions involve generic patterns of layer-specific interactions and frequency specific neuronal activity. In summary, this interdisciplinary project will employ a novel cutting-edge methodological approach to establish next generation connectomics of the human brain. This may provide fundamental new insights into the large-scale computational principles underlying human cognition and behavior.

• DFG Programme: Priority Programmes
• Subproject of: SPP 2041: Computational Connectomics
• Ehemalige Antragstellerin: Privatdozentin Dr. Gabriele Lohmann, until 6/2024