Superconducting FT-NMR-Spectrometer 700 MHz

• Subject Area: Molecular Chemistry
• Term: Funded in 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 455080901

High-resolution NMR spectroscopy is one of the most important modern analytical instruments in chemistry. There is currently an urgent need for action in this area at the Justus Liebig University to acquire a modern 700 MHz NMR spectrometer with an N2-cooled probe head, to improve the currently insufficient detection sensitivity when measuring small amounts from synthesis and natural product isolation and when measuring less sensitive hetero-nuclei with small amounts of substance. The NMR department of the Institute of Organic Chemistry is the only department of its kind within the university and is therefore responsible for all measurements, including those from related fields. Access to high-performance NMR analysis is essential for many working groups, for whom NMR spectroscopy is of central importance. At the moment, the sensitivity and resolution of our largest NMR spectrometer (600 MHz) are only conditionally sufficient to carry out the structure elucidation of the smallest amounts of substances and poorly soluble compounds. In particular, the probe head configuration of our largest NMR spectrometer, a 5 mm broadband probe head with automatic tuning (ATM, 13 years old and often in need of repair) and a 5 mm triple resonance inverse probe head without automatic tuning is too insensitive for the investigation of small amounts and analyses of natural product isolates. Also, suppression of solvents and lengthening of measuring times are not efficient enough for a complete structural analysis of very small quantities. A 700 MHz NMR spectrometer with an N2-cooled probe head would allow, due to its higher resolution and sensitivity, the smallest amounts of substances and poorly soluble compounds to be investigated, which can only be processed inadequately with the available equipment. The requested device is also of crucial importance for the maintenance and expansion of our competencies in the field of NMR structure analysis, also beyond the institutes in chemistry. The life sciences profile area of the Justus-Liebig University is to be expanded and supported through further development and cooperation with strong partners. For instance, the aim of "Insect Biotechnology" as an innovative and future-oriented research field of the Justus Liebig University and the new project group "Bioresources" is to identify new active substances in domestic insects that are used in medicine, crop protection or in food biotechnology. In this context, the requested 700 MHz NMR spectrometer enables us to work on new research areas and thus create the basis for further cooperation within and outside the university, which greatly increases the competitiveness of the Justus Liebig University in the field of structural analysis.

• DFG Programme: Major Research Instrumentation
• Major Instrumentation: Supraleitendes FT-NMR-Spektrometer 700 MHz (Teilfinanzierung)
• Instrumentation Group: 1740 Hochauflösende NMR-Spektrometer
• Applicant Institution: Justus-Liebig-Universität Gießen
• Leader: Professor Dr. Peter R. Schreiner