Spatiotemporal regulation of sprouting angiogenesis through combined mechanical and geometrical cues
(P10)
Subject Area
Medical Informatics and Medical Bioinformatics
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 427826188
Vascularization is tightly interlinked with tissue mineralization during bone regeneration. Impaired angiogenesis leads to a failure of the bone regeneration process with delayed or non-union outcomes. Mechanical signals are known to impact vascularization with consequences for the bone healing process. In this project, we aim to investigate how local mechanical tissue strains and extracellular matrix properties (composition, patterning) influence the growth of vessels. Towards this aim, we will combine an in vitro 3D bone defect model with computer simulations to quantify the spatial distribution of mechanical strains and to investigate the respective cellular response leading to vessel growth. We hypothesize that mechanical and geometrical signals can be synergized in architectural scaffold designs to control re-vascularization for improved bone defect healing
DFG Programme
Collaborative Research Centres
