Project Details
Projekt
Imaging of immune cell dynamics and host-pathogen interactions in gut-associated lymphoid tissue during Yersinia pseudotuberculosis infections (C07)
Subject Area
Immunology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824
Intestinal infections with Yersinia pseudotuberculosis cause invasion into the gut-associated lymphoid tissues and immune cell recruitment, mainly neutrophils, leading to spatiotemporal re-shaping of the immune response. We found that not only the local environment in infected tissues but also the injection of Yersinia effector proteins (Yops) by the bacteria changed neutrophil abundance and phenotypes. To dissect the mechanism and consequences of this process, we will combine in vivo and in vitro experiments using genetically modified bacteria and mice in disease models using tissue-scale and whole-body imaging.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Münster
Project Heads
Professorin Dr. Petra Dersch; Professor Dr. Jan Rossaint
