Nanocarrier-based functional analysis of myeloid cells in inflammatory and autoimmune skin diseases (C06)

• Subject Area: Dermatology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824

A key feature of cutaneous inflammatory diseases is the infiltration of myeloid cells into the skin. However, the role and crosstalk of subpopulations of myeloid cells, their interaction and the role of ROS stress in myeloid cell biology are largely unknown in the pathogenesis of inflammatory skin disorders. We will combine novel nanocarrier-based approaches with functional and multiscale imaging techniques in mouse models of acute (allergic contact dermatitis) and chronic (systemic sclerosis) cutaneous inflammation to unravel molecular mechanisms of myeloid cell biology and of ROS-mediated processes in inflammatory and autoimmune skin diseases.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1450: Multiscale imaging of organ-specific inflammation
• Applicant Institution: Universität Münster
• Project Heads: Professorin Dr. Katharina Landfester; Professorin Dr. Kerstin Steinbrink