Project Details
Projekt
Multiscale visualisation and analysis of innate immune cell migration at sites of hypoxic inflammation in vivo (B04)
Subject Area
Cell Biology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824
Access to molecular oxygen is essential for cell function and behaviour. Tools to measure this central parameter, in particular in vivo, are limited. We have generated a hypoxia reporter mouse, which we will characterize and use to understand the action of immune cells in acute and chronic hypoxia. We have developed dedicated deep learning pipelines that will be extended and accompanied by complementary annotation and supervision tools, to analyse hypoxia across scales. The combination of these approaches will provide unprecedented insights into the dynamics and consequences of hypoxia and its connection to inflammation.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Münster
Project Heads
Professor Dr. Friedemann Kiefer; Professor Dr. Benjamin Risse
