Metabolic targeting of bacteria through complex carbohydrates and siderophores (A04)

• Subject Area: Nuclear Medicine, Radiotherapy, Radiobiology
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824

We aim to develop reliable diagnostic tools to differentiate between sterile inflammation and bacterial infection. We will design radiolabelled specific imaging probes based on oligosaccharides, siderophores and metallophores that are selectively taken up by bacteria. These tracers will be tested in vitro as well as in vivo using Gram-positive and Gram-negative bacteria, allowing us to assess potential clinical applications. In mouse models, we will non-invasively follow bacterial infection and the inflammatory response over time using novel tracers developed in this and other projects in this CRC.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1450: Multiscale imaging of organ-specific inflammation
• Applicant Institution: Universität Münster
• Project Heads: Dr. Andreas Faust; Professor Dr. Ryan Gilmour, until 12/2024; Privatdozentin Dr. Silke Niemann