Targeting of S100A8/A9 for imaging of inflammatory disorders (A03)

Subject Area Nuclear Medicine, Radiotherapy, Radiobiology
Term since 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824
 

Project Description

Activated monocytes and granulocytes are key to inflammatory diseases and release the alarmin S100A8/A9 in high concentrations, triggering sterile as well as infectious inflammatory processes via TLR-4. In the proposed project we will establish a specific S100A8/A9 tracer combining X-ray structure analysis and chemical synthesis. The tracer core will be linked to different labels suited for PET, SPECT, fluorescent or photoacoustic imaging techniques. In summary, we will create a new toolset to monitor the onset of inflammatory responses, the spatio-temporal location and resolution of inflammation in the context of the whole organism.
DFG Programme Collaborative Research Centres
Subproject of SFB 1450:  Multiscale imaging of organ-specific inflammation
Applicant Institution Universität Münster
Project Heads Dr. Andreas Faust; Privatdozent Dr. Günter Fritz