Targeting of S100A8/A9 for imaging of inflammatory disorders
(A03)
Subject Area
Nuclear Medicine, Radiotherapy, Radiobiology
Term
since 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824
Activated monocytes and granulocytes are key to inflammatory diseases and release the alarmin S100A8/A9 in high concentrations, triggering sterile as well as infectious inflammatory processes via TLR-4. In the proposed project we will establish a specific S100A8/A9 tracer combining X-ray structure analysis and chemical synthesis. The tracer core will be linked to different labels suited for PET, SPECT, fluorescent or photoacoustic imaging techniques. In summary, we will create a new toolset to monitor the onset of inflammatory responses, the spatio-temporal location and resolution of inflammation in the context of the whole organism.
DFG Programme
Collaborative Research Centres
