Tailored coordination compounds as multimodal labels for multiscale imaging (A02)

• Subject Area: Inorganic Molecular Chemistry - Synthesis and Characterisation
• Term: since 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 431460824

We will elucidate the role of capillary mesenteric lymph vessels in peritoneal lymph drainage and inflammatory disease progression. Hence, the coordination-chemical concepts established in the first funding period will be implemented towards small molecules as functional labels. Their biodistribution profiles will be tuned by the amphiphilicity or by specific targeting units; since the chelator can remain invariant, no modification of the localization is expected upon exchange of the central cation. Thus, multiple orthogonal readouts arising from a single label will be used to visualize the early pathogen transport of Y. pseudotuberculosis in mice bridging the gap between different scales and modalities.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1450: Multiscale imaging of organ-specific inflammation
• Applicant Institution: Universität Münster
• Project Heads: Dr. Stefanie Bobe, since 1/2025; Professor Dr. Cristian Alejandro Strassert