Provenance mapping of immune cells in the CSF (A12*)

• Subject Area: Clinical Neurology; Neurosurgery and Neuroradiology
• Term: from 2021 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 213904703

The initial phases of immunopathology in the CNS in MS are dictated by the systemic immune compartment. However, it is unknown in which sites of the immune system specific properties of immune cells that later traffic to the CNS are imprinted. Here, we will use an in vivo labeling system to track immune cells from the inguinal or mesenteric lymph nodes to the CNS. By single cell analysis of the trancriptome and the TCR and BCR of lymphocytes reisolated from the CNS and cereprospinal fluid of EAE mice, we will correlate the mesenteric or inguinal provenance of these lymphocytes with their distinct properties in the CNS.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 128: Initiating/Effector versus Regulatory Mechanisms in Multiple Sclerosis - Progress towards Tackling the Disease
• Applicant Institution: Universität Münster
• Project Heads: Professor Dr. Thomas Korn; Privatdozent Dr. Klaus Lehmann-Horn, until 1/2021