MOG Antibody-Induced CNS Demyelination: from Specificity to Function
(A11*)
Subject Area
Clinical Neurology; Neurosurgery and Neuroradiology
Term
from 2021 to 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 213904703
IgG antibodies (Abs) specific for central nervous system (CNS) antigens such as myelin oligodendrocytes glycoprotein (MOG) are considered crucial effector molecules in some patients with multiple sclerosis (MS) and related diseases. In the proposed project, we will characterize structural requirements for immune recognition of human MOG and determine IgG-Fc biophysical profiles and effector functions linked to in vivo pathogenicity of human MOG-Abs.
DFG Programme
CRC/Transregios
