400 MHz NMR console für solid-state-NMR

• Subject Area: Basic Research in Biology and Medicine
• Term: Funded in 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 447235569

DNP-enhanced solid-state NMR offers an increase in sensitivity by orders of magnitude. It opens the door to new, unconventional NMR experiments and especially the analysis of samples with low spin numbers. We use this technique especially for the study of membrane proteins and in particular for probing subunit interactions within large complexes, for analyzing low-populated intermediate states and for small molecules in complex with transporters or receptors. Protein families of interest are GPCRs, ABC transporter, kinases and photoreceptors. In order to continue and to expand these studies, an outdated NMR console within the excising DNP-NMR spectrometer needs to be replaced, which is the aim of this proposal.

• DFG Programme: Major Research Instrumentation
• Major Instrumentation: 400 MHz NMR Konsole für Festkörper-NMR
• Instrumentation Group: 1741 Festkörper-NMR-Spektrometer
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Leader: Professor Dr. Clemens Glaubitz