TH receptor-clock interaction in NAFLD development (P13+)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: from 2020 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 424957847

Circadian clocks regulate organ responses to external stimuli such as TH through tissue-specific transcriptional programmes. In the liver, many TH target genes show robust circadian regulation, demonstrating temporal modulation of local TH action – despite largely constant tissue T3 levels. We will analyse clock-TRβ interaction in the regulation of hepatic lipid metabolism in mice with genetic disruption of liver clock or TR signalling and test this interaction as a potential TRβ-targeted (chrono-)therapy for fatty liver disease.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 296: Local control of TH action (LocoTact)
• Applicant Institution: Universität Duisburg-Essen
• Project Head: Professor Dr. Henrik Oster