Role of mitochondria in the regulation of myeloid cell function in skin homeostasis and repair
(B10)
Subject Area
Dermatology
Immunology
Term
since 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409
In the previous funding phase, we showed that mitochondrial metabolism coordinates the stage-specific activation and effector functions of macrophages to ensure effective wound healing in the skin. Based on our findings, we propose in the next funding period to further unravel the molecular signals that mediate the dynamics of mitochondrial metabolism and to decipher how metabolic rewiring is linked to macrophage function over the time course of wound healing. The long-term goal of this project is to understand how mitochondrial metabolism in macrophages regulates tissue repair and ultimately advance the development of therapeutic approaches to improve wound healing disorders in patients.
DFG Programme
Collaborative Research Centres
