Genetic and epigenetic characterization of chronic lymphocytic leukemia with translocations involving the immunoglobulin loci (B10*)

• Subject Area: Hematology, Oncology ; Human Genetics
• Term: from 2020 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 217328187

Although 10% of CLL harbor translocations involving immunoglobulin genes (IG), their biological and prognostic impact as well as translocation partner genes remain largely unclear. Therefore, we will perform targeted capture sequencing on ~200 IG-translocated CLL cases to identify novel translocation partner genes. Moreover, we will comprehensively describe the genetic and epigenetic landscape of these cases. Functional characterization of recurrent known (e.g. BCL3/PVRL2) and selected novel partner genes will be performed. Correlation of molecular and clinical findings shall enhance our understanding on disease biology and classification and inform on deregulated pathways providing potential new therapeutic targets.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1074: Experimental Models and Clinical Translation in Leukemia
• Applicant Institution: Universität Ulm
• Project Heads: Dr. Anja Mottok, until 12/2020; Professor Dr. Reiner Siebert