Molecular mechanisms of tumorigenesis in primary aldosteronism

• Applicants: Professor Dr. Martin Reincke; Tracy Ann Williams, Ph.D.
• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: from 2020 to 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 444776998

The primary objective of this proposal is to delineate the molecular mechanisms that lead to dysregulated tumor growth of aldosterone-producing adenomas (APAs) using RNA-seq to compare the transcriptional profiles of APAs stratified by nodule diameter and genotype. Secondly, we will investigate the mechanism of tumourigenesis of aldosterone-producing cell cluster to APA transition by metabolite profiling of adrenal lesions in PA using in situ matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI). The long term aim of our work is to improve the diagnosis and management of PA in line with the translational research goals of the PA group in Munich.

• DFG Programme: Research Grants