Mechanisms and consequences of inflammasome mediated mitochondrial impairment in Mycobacterium tuberculosis infected myeloid cells (B05)

• Subject Area: Immunology ; Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 414786233

Mycobacterium tuberculosis (Mtb) is a highly successful intracellular pathogen based on its ability to manipulate innate immunity countermeasures of its major host, the human macrophage. Lytic host cell death is essential for bacterial dissemination and represents an important research topic both mechanistically and from a therapeutic perspective. This project aims to study the mechansims and cosequences of Mtb induced regulated cell death and mitochondrial damage in infected myeloid cells and noninfected bystander cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1403: Cell Death in Immunity, Inflammation and Disease
• Applicant Institution: Universität zu Köln
• Project Head: Professor Jan Rybniker, Ph.D.