The role of mitochondria for cellular protection against ferroptosis
(A06)
Subject Area
Biochemistry
Cell Biology
Term
since 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 414786233
Mitochondria play an active role in cell death control and are emerging as central regulators of innate immunity. In addition to their well-described role in apoptosis, mitochondria have also been linked to other modes of regulated cell death, such as necroptosis, ferroptosis and pyroptosis. This project will examine how the mitochondrial i-AAA protease YME1L regulates cell survival, and inflammatory responses on a molecular level and how this relates to neurodegeneration and tissue-specific cell death in vivo. These studies will help define the role of mitochondria at the interface between cell death and inflammation.
DFG Programme
Collaborative Research Centres