The role of mitochondria for cellular protection against ferroptosis (A06)

Mitochondria play an active role in cell death control and are emerging as central regulators of innate immunity. In addition to their well-described role in apoptosis, mitochondria have also been linked to other modes of regulated cell death, such as necroptosis, ferroptosis and pyroptosis. This project will examine how the mitochondrial i-AAA protease YME1L regulates cell survival, and inflammatory responses on a molecular level and how this relates to neurodegeneration and tissue-specific cell death in vivo. These studies will help define the role of mitochondria at the interface between cell death and inflammation.

DFG Programme Collaborative Research Centres

Subproject of SFB 1403:  Cell Death in Immunity, Inflammation and Disease

Applicant Institution Universität zu Köln

Project Head Professor Dr. Thomas Langer