Molecular pathways of gasdermin pore formation and repair (A04)

• Subject Area: Immunology
• Term: since 2020
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 414786233

While work in the first funding phase has contributed to the molecular understanding of pore formation by gasdermin D (GSDMD) as a major effector for inflammation downstream of inflammasome assembly, we still do not understand the mechanistic details of activation, regulation, and removal of other gasdermin family members. This project will employ camelid nanobodies to visualize and manipulate pore formation by GSDMA, GSDMD, and GSDME to uncover the molecular underpinnings of physiological and pathological roles of gasdermins.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1403: Cell Death in Immunity, Inflammation and Disease
• Applicant Institution: Universität zu Köln
• Project Heads: Professor Dr. Eicke Latz, until 12/2023; Professor Dr. Florian Ingo Schmidt