Mechanisms of cell death-induced inflammation (A01)

Studies in mouse models provided evidence that cell death triggers inflammation, however the underlying mechanisms remain elusive. Using relevant genetic mouse models, this project will study the mechanisms by which different types of cell death trigger inflammation in vivo, focusing on apoptosis, necroptosis and pyroptosis. Major focus areas will be the in vivo role of specific DAMPs and their receptors as well as the mechanisms determining DAMP release via plasma membrane permeabilization and their functional consequences in triggering cell death-induced inflammation.

DFG Programme Collaborative Research Centres

Subproject of SFB 1403:  Cell Death in Immunity, Inflammation and Disease

Applicant Institution Universität zu Köln

Project Head Professor Dr. Manolis Pasparakis