The role of the meninges in the resolution of acute autoimmune CNS lesions
(A04)
Subject Area
Molecular and Cellular Neurology and Neuropathology
Term
since 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 408885537
The meninges are an important anatomical checkpoint for CNS autoinflammatory diseases, as this is where immune cells are recruited and where they can chronically persist. We propose that CNS persistent inflammation alters the meningeal milieu, particularly the vessels, creating a chronic inflammatory environment. This sustained inflammation impedes CNS recovery from acute damage. Our research aims to identify, in animal models and human samples of multiple sclerosis, cells and factors in the meninges that drive chronic inflammation in MS, ultimately identifying new drug targets for CNS recovery.
DFG Programme
CRC/Transregios
