The role of the meninges in the resolution of acute autoimmune CNS lesions (A04)

Subject Area Molecular and Cellular Neurology and Neuropathology
Term since 2020
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 408885537
 

Project Description

The meninges are an important anatomical checkpoint for CNS autoinflammatory diseases, as this is where immune cells are recruited and where they can chronically persist. We propose that CNS persistent inflammation alters the meningeal milieu, particularly the vessels, creating a chronic inflammatory environment. This sustained inflammation impedes CNS recovery from acute damage. Our research aims to identify, in animal models and human samples of multiple sclerosis, cells and factors in the meninges that drive chronic inflammation in MS, ultimately identifying new drug targets for CNS recovery.
DFG Programme CRC/Transregios
Subproject of TRR 274:  Checkpoints of Central Nervous System Recovery
Applicant Institution Georg-August-Universität Göttingen
Project Heads Dr. Arianna Merlini, since 1/2024; Professorin Dr. Francesca Odoardi