Chronic inflammasome activation in post-stroke recovery

Applicants Professor Dr. Veit Hornung; Professor Dr. Arthur Liesz; Privatdozentin Dr. Antje Schmidt-Pogoda
Subject Area Molecular and Cellular Neurology and Neuropathology
Molecular Biology and Physiology of Neurons and Glial Cells
Term since 2019
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 405358801
 

Project Description

In our collaborative project, we want to understand how inflammasome activation is involved in chronic neuroinflammation after stroke. Expanding on our findings from the first funding period, we want to address now the mechanisms which lead contributing to chronic inflammasome activation and analyze the impact of inflammasome activation on long-range neuronal connectivity. Specifically, we will analyze dysfunctional lipid metabolism as a cause of inflammasome activation in immune and non-immune cells of the brain. We will focus on reorganization of the corticospinal tract after stroke to study the role of inflammasome activation on neuronal plasticity.
DFG Programme Research Units
Subproject of FOR 2879:  ImmunoStroke: From immune cells to stroke recovery