Untersuchungen über die therapeutische Bedeutung menschlicher ßi- und p2-Adrenozeptor Polymorphismen.

Applicant Professor Dr. Gerd Heusch, since 11/2007

Subject Area Anatomy and Physiology

Term from 2007 to 2010

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 42840151

Final Report Year 2010

Final Report Abstract

No abstract available

(2009) A novel functional haplotype in the human GNAS gene alters Gas expression, responsiveness to ß-adrenoceptor stimulation, and peri-operative cardiac performance. Eur Heart J 30:1402-1410
Frey UH, Adamzik M, Kottenberg-Assenmacher E, Jakob H, Manthey I, Broecker-Preuss M, Bergmann L, Heusch G, Siffert W, Peters J, Leineweber K
(2009) beta(1)- and beta(2)-Adrenoceptor polymorphisms and cardiovascular diseases. Br J Pharmacol 158:61-69
Leineweber K, Heusch G
(2010) Increased inducible nitric oxide synthase and arginase II expression in heart failure: No net nitrite/nitrate production and protein S-nitrosylation. Am J Physiol Heart Circ Physiol 299:H446-H453
Heusch P, Aker S, Boengler K, Deindl E, van de Sand A, Klein K, Rassaf T, Konietzka I, Sewell A, Menazza S, Canton M, Heusch G, Di Lisa F, Schulz R
(2010) The Arg16Gly-beta(2)-adrenoceptor single nucleotide polymorphism: exercise capacity and survival in patients with end-stage heart failure. Naunyn-Schmiedeberg's Arch Pharmacol 382:357-365
Leineweber K, Frey UH, Tenderich G, Toliat MR, Zittermann A, Nürnberg P, Körfer R, Siffert W, Heusch G
(2010) The contribution of reactive oxygen species and p38 mitogen activated protein kinase to myofilament oxidation and progression of heart failure in rabbits. Br J Pharmacol 160:1408-1416
Heusch P, Canton M, Aker S, van de Sand A, Konietzka I, Rassaf T, Menazza S, Brodde OE, Di Lisa F, Heusch G, Schulz R