Entschlüsselung des mRNP Codes bei der erfolgreichen Reprogrammierung von Gliazellen zu Nervenzellen

• Antragsteller: Professor Dr. Michael Kiebler; Professor Dr. Jovica Ninkovic, Ph.D.
• Fachliche Zuordnung: Allgemeine Genetik und funktionelle Genomforschung ; Entwicklungsbiologie ; Zellbiologie
• Förderung: Förderung von 2019 bis 2024
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 427451793

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Choroid plexus‐derived miR‐204 regulates the number of quiescent neural stem cells in the adult brain. The EMBO Journal, 38(17).
  Lepko, Tjasa; Pusch, Melanie; Müller, Tamara; Schulte, Dorothea; Ehses, Janina; Kiebler, Michael; Hasler, Julia; Huttner, Hagen B; Vandenbroucke, Roosmarijn E; Vandendriessche, Charysse; Modic, Miha; Martin‐Villalba, Ana; Zhao, Sheng; LLorens‐Bobadilla, Enric; Schneider, Anja; Fischer, Andre; Breunig, Christopher T; Stricker, Stefan H; Götz, Magdalena & Ninkovic, Jovica
  
• RNA-binding proteins balance brain function in health and disease. Physiological Reviews, 101(3), 1309-1370.
  Schieweck, Rico; Ninkovic, Jovica & Kiebler, Michael A.
  
• TDP-43 condensates and lipid droplets regulate the reactivity of microglia and regeneration after traumatic brain injury. Nature Neuroscience, 25(12), 1608-1625.
  Zambusi, Alessandro; Novoselc, Klara Tereza; Hutten, Saskia; Kalpazidou, Sofia; Koupourtidou, Christina; Schieweck, Rico; Aschenbroich, Sven; Silva, Lara; Yazgili, Ayse Seda; van Bebber, Frauke; Schmid, Bettina; Möller, Gabriel; Tritscher, Clara; Stigloher, Christian; Delbridge, Claire; Sirko, Swetlana; Günes, Zeynep Irem; Liebscher, Sabine; Schlegel, Jürgen; ... & Ninkovic, Jovica
  
• Fear extinction is regulated by the activity of long noncoding RNAs at the synapse. Nature Communications, 14(1).
  Liau, Wei-Siang; Zhao, Qiongyi; Bademosi, Adekunle; Gormal, Rachel S.; Gong, Hao; Marshall, Paul R.; Periyakaruppiah, Ambika; Madugalle, Sachithrani U.; Zajaczkowski, Esmi L.; Leighton, Laura J.; Ren, Haobin; Musgrove, Mason; Davies, Joshua; Rauch, Simone; He, Chuan; Dickinson, Bryan C.; Li, Xiang; Wei, Wei; Meunier, Frédéric A.; ... & Bredy, Timothy W.
  
• Shared inflammatory glial cell signature after brain injury, revealed by spatial, temporal and cell-type-specific profiling of the murine cerebral cortex. American Geophysical Union (AGU).
  Koupourtidou Christina, Schwarz Veronika; Aliee Hananeh, Frerich Simon; Fischer-Sternjak Judith, Bocchi Riccardo; Simon-Ebert Tatiana, Dichgans Martin; Götz Magdalena, Theis Fabian & Ninkovic Jovica
  
• Ribosome inactivation regulates translation elongation in neurons. Journal of Biological Chemistry, 300(2), 105648.
  Popper, Bastian; Bürkle, Martina; Ciccopiedi, Giuliana; Marchioretto, Marta; Forné, Ignasi; Imhof, Axel; Straub, Tobias; Viero, Gabriella; Götz, Magdalena & Schieweck, Rico