Maturase assemblies in cytochrome c biogenesis (A04)

• Subject Area: Biochemistry
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403222702

C-type cytochromes contain one or multiple covalently linked heme cofactors. Heme attachment is mediated by maturases that scan the nascent peptide upon membrane translocation and recognize conserved binding motifs. In this project we will characterize the components and submodules of the two most versatile maturases, the Ccm and Ccs system, in structural and functional aspects and also investigate the dynamic association of the maturases with the Sec translocon.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1381: Dynamic organization of cellular protein machineries: From biogenesis and modular assembly to function
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Oliver Einsle