GUARD – Genes Underlying AoRtic valve Disease (B07)

• Subject Area: Cardiology, Angiology ; Human Genetics
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 397484323

Aortic stenosis (AS) affects 5% of individuals over 70 years of age. In the vast majority of cases AS has a multifactorial etiology, i.e. it involves a combination of the cumulative effect of genetic risk variants and environmental factors. Through our scientific network GUARD we will elucidate the genetic mechanisms underlying AS in a genome-wide fashion. In addition to patients with severe AS, moderate AS patients will be included and followed up to understand genetic determinants of slow and fast progression.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 259: Aortic Disease
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Dr. Baravan Al-Kassou, since 4/2021; Professor Dr. Markus M. Nöthen; Dr. Jan-Malte Sinning, until 4/2020; Dr. Vedat Tiyerili, from 5/2020 until 3/2021