Project Details
Projekt
Mode of action of rhodomyrtone (Rom) and synthesized derivatives and studying the resistance mechanism mediated by FarE / FarR (A04)
Subject Area
Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
Term
from 2019 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 398967434
Rhodomyrtone (Rom) is an antibiotic that is active against many multi-resistant Gram-positive bacteria. A Rom-resistant Staphylococcus aureus mutant (RomR) has been isolated. Our preliminary studies suggest that FarR (a regulator) and FarE (a proposed fatty acid efflux pump) are causative for the resistance. Here, we want to study how FarE and FarR mediate resistance to Rom and probably other antibiotics. The chemical synthesis of Rom-derivatives is crucial to unravel the FarE substrate specificity.
DFG Programme
CRC/Transregios
Applicant Institution
Eberhard Karls Universität Tübingen
Project Heads
Professor Dr. Friedrich Götz; Professor Dr. Martin E. Maier
