Immune-mediated pathology as a consequence of impaired lymphocyte-extracellular matrix interactions
(B03)
Subject Area
Dermatology
Immunology
Term
since 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 256073931
This project will be based on insights of the last funding period on B cell development along the collagen VII-laminin-332-integrin axis in secondary lymphoid organs. The functional implications of collagen deficiency for B cell development towards an autoimmune-associated phenotype will be further mechanistically interrogated. Given the demonstration of autoantibody-driven autoimmunity as a driver of advanced disease in dystrophic epidermolysis bullosa (DEB), B03 will also evaluate proteasome inhibition or neonatal Fc receptor antagonism as a therapeutic approach to control autoimmune- and inflammation-driven organ damage in DEB mice.
DFG Programme
Collaborative Research Centres
