Topology and function of secretory antibodies in gut-liver communication (B06)

• Subject Area: Immunology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403224013

Secretory immunoglobulins (SIg) confer protection against toxins and pathogens. Additionally, SIg bind to gut microbiota affecting microbial metabolism, growth, motility, bile acid sensitivity and host-microbe interaction. Project B06 studies how microbiota-directed antibody responses are generated in the gut-liver unit, develops a framework integrating biliary and intestinal IgA transport and function and characterises the impact of SIg on barriers in gut and liver. These approaches will reveal antigen-specific and antigen-specificity-independent functions of SIg in the gut-liver axis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1382: Gut-liver axis – Functional circuits and therapeutic targets
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Head: Professor Dr. Oliver Pabst