Impact of gut-liver communication on hepatic macrophage composition and function (B05)

• Subject Area: Gastroenterology ; Immunology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403224013

Liver macrophages represent the gatekeepers against gut-derived antigens, maintain homeostasis and can promote liver disease progression. Project B05 will study how gut-derived signals modulate the composition and phenotypic activation of hepatic macrophages, thereby determining their functional roles in liver homeostasis and disease. Understanding the molecular and cellular mechanisms involved in this aspect of the gut-liver axis, particularly in the macrophage – ductular cell crosstalk, might open new avenues for therapeutic interventions in patients with liver diseases.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1382: Gut-liver axis – Functional circuits and therapeutic targets
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Dr. Adrien Guillot, since 7/2023; Professor Dr. Frank Tacke, Ph.D.