Coordination of gut-liver communication through directed immune cell migration (B02)

• Subject Area: Immunology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403224013

Directed migration of immune cells is controlled by the expression of chemokines and adhesion molecules (AM). Misdirected immune cell migration contributes to the pathogenesis of inflammatory diseases. Project B02 studies AM-dependent immune cell subsets that circulate between the liver and gut, affect microbiota composition and either prevent or promote gut-associated liver disease in mice. In addition, innate immune cells that depend on the AM β7 integrin and contribute to metabolic dysregulation and meta-inflammation will be characterised. Such information is a prerequisite for effective targeting of AM in gastrointestinal diseases.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1382: Gut-liver axis – Functional circuits and therapeutic targets
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Dr. Angela Schippers; Professor Dr. Norbert Wagner