Consequences of bile-salt signalling for liver regeneration and pathophysiology (A07)

Signalling via host- and gut microbe-derived bile salts is involved in liver regeneration after partial hepatectomy. Cholestatic sequela impair the regenerative process and cause significant mortality in patients with perihilar cholangiocarcinoma, despite pre-operative biliary drainage. Project A07 studies how the interplay between cholestasis and drainage-related infections affects liver regeneration in post-cholestatic patients and defines underlying principles in mice. The combined approaches will reveal their reciprocal impact on regrowth of the post-cholestatic liver, and involved gut-liver mediators.

DFG Programme Collaborative Research Centres

Subproject of SFB 1382:  Gut-liver axis – Functional circuits and therapeutic targets

Applicant Institution Rheinisch-Westfälische Technische Hochschule Aachen

Project Heads Professor Steven Olde Damink, Ph.D.; Frank G. Schaap, Ph.D.