Molecular signatures underlying pathological gut-liver crosstalk and liver regeneration
(A04)
Subject Area
Nuclear Medicine, Radiotherapy, Radiobiology
Analytical Chemistry
Anatomy and Physiology
Biochemistry
Term
since 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 403224013
The portal vein is an essential compartment of the gut-liver axis and the molecular composition of portal vein blood can provide new insights into gut-liver crosstalk. Project A04 studies biomarkers and potential novel mediators of a pathological gut-liver crosstalk by analysing portal vein blood from patients with portal hypertension using mass spectrometry and molecular studies. Also, A04 studies blood biomarkers, molecular radiologic imaging markers and a predictive model for partial liver regeneration after portal vein embolisation in patients. Combined, this will reveal molecular signatures underlying pathological gut-liver crosstalk and liver regeneration.
DFG Programme
Collaborative Research Centres