The role of proteotoxic stress in the gut-liver axis
(A03)
Subject Area
Gastroenterology
Term
since 2019
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 403224013
Primary sclerosing cholangitis (PSC) is a hallmark of the gut-liver axis and characterised by simultaneous intestinal and biliary injury. Previously, we studied epithelial factors that may trigger PSC phenotype and also expanded our knowledge of the proteotoxic disorder alpha1-antitrypsin deficiency (AATD). Project A3 will further examine the emerging impact of gut-liver axis-related factors on AATD-related liver injury. The proteotoxic stress in inflammatory and intestinal cells and their response to gut-liver axis-related factors will be tested. An iterative assessment of human samples and experimental models will uncover the importance of the gut-liver axis in AATD.
DFG Programme
Collaborative Research Centres
