Microbiota and TLR-Signalling in the Development and Recurrence of intrahepatic Cholangiocarcinoma (A01)

• Subject Area: Gastroenterology ; General and Visceral Surgery
• Term: from 2019 to 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403224013

The exact role of microbiota and toll-like-receptor (TLR)-signalling in intrahepatic cholangiocarcinoma (iCCA) is not well defined. In the project we will evaluate how signals triggered by the intestinal microbiota modulate the development of cholangiocarcinoma in a genetic murine tumour model. Moreover, we will examine the role of gut microbiota in the recurrence of iCCA as a proof-of principle for adjuvant treatment strategies. Finally, the translation of findings from the murine models into human patients will achieved by using specimen from an interventional clinical trial (ARROW-Trial) on selective microbiome-targeted modifications in liver tumour patients.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1382: Gut-liver axis – Functional circuits and therapeutic targets
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Heads: Professor Tom Lüdde, Ph.D.; Professor Dr. Ulf P. Neumann