Direct electrochemical functionalizations of unactivated C–H bonds for the late stage modification of complex structures

• Applicant: Dr. Gary N. Hermann
• Subject Area: Organic Molecular Chemistry - Synthesis and Characterisation
• Term: from 2018 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 419055018

• Final Report Year: 2021

Final Report Abstract

The research of this fellowship has not only great significance in the field of electrochemistry but also within the area of chemical biology and the pharmaceutical sector. It enables the active site labeling of various biomolecules under physiological conditions by using a small 4-membered ring system and electrochemistry, successfully extending the toolbox of chemical biology. This novel electrochemical approach has the potential to facilitate drug discovery, the isolation of unknown proteins, reveal protein-protein-interactions and visualize important biochemical processes. Moreover, it might reduce the interruption of important cellular functions compared to established methods.