Deconstructing the role of HIPK2 in DNA repair and genome stability (19)

• Subject Area: Biochemistry
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 393547839

This project aims at clarifying mechanisms and pathways influencing DNA double-strand break repair path-way choice and at understanding how these are interlinked to cell fate choice upon DNA damage. We have identified novel signalling modules that impact on DSB repair upon DNA damage. These modules will be mechanistically and functionally analysed in the context of endogenous lesions with a focus on the replicative stress response.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1361: Regulation of DNA Repair and Genome Stability
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Head: Professor Thomas G. Hofmann, Ph.D.