Vascular control of tumor immunity in the central nervous system (C01)

• Subject Area: Cardiology, Angiology ; Molecular and Cellular Neurology and Neuropathology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 394046768

Project C01 is aimed at switching the brain vasculature to support the immune responses to tumors. Based on the findings from the first funding period, the work will be aimed at validating the role of the candidate gene A20/TNFAIP3 for angiocrine neuroinflammation and at exploiting the effect of vascular heterogeneity and senescence on anti-glioma immunity in murine models and human tissues. The project is expected to yield translatable results that will build for the foundation for novel strategies to enhance anti-tumor immunity and improve immunotherapeutic approaches in brain tumor patients.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1366: Vascular Control of Organ Function
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Professor Dr. Michael Platten; Dr. Katharina Sahm