Targeting collecting duct barrier function for renoprotection (C06)

• Subject Area: Nephrology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 394046635

The renal collecting duct is composed of a tight epithelium that maintains steep concentration gradients between the renal medullary interstitium and the urinary space and, at the same time, facilitates highly regulated transport mechanisms for water and ions. In this project, we will analyze the physiological, cellular and molecular mechanisms and consequences of collecting duct injury during and after acute kidney injury, and its role in limiting the progression to chronic kidney disease. We will utilize cellular and murine models of acute kidney injury and combine them with genetic and pharmacologic approaches to modulate collecting duct epithelial barrier function.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1365: Renoprotection
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Head: Professor Dr. Kai Schmidt-Ott