Microbiota- and TLR-dependent regulation of intestinal tumor development (P10)

• Subject Area: Gastroenterology
• Term: from 2019 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 395357507

Microbial factors can either promote or inhibit intestinal tumor development through activation of various TLR (toll-like-receptor)-dependent pathways. Here we aim to analyze whether specific microbial taxa are responsible for promoting tumor compared to tumor-suppressive effects in mouse models of colorectal cancer (CRC). We also aim to dissect the tumor-suppressive effects of TRIF/TLR3 signaling with the help of genetically engineered mouse models. The translational relevance of the preclinical findings will be evaluated using two large, independent human CRC cohorts.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1371: Microbiome Signatures -- Functional Relevance in the Digestive Tract
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professor Dr. Klaus-Peter Janssen; Professor Dr. Sebastian Zeissig