Microbiota- and TLR-dependent regulation of intestinal tumor development (P10)

Subject Area Gastroenterology
Term from 2019 to 2022
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 395357507
 

Project Description

Microbial factors can either promote or inhibit intestinal tumor development through activation of various TLR (toll-like-receptor)-dependent pathways. Here we aim to analyze whether specific microbial taxa are responsible for promoting tumor compared to tumor-suppressive effects in mouse models of colorectal cancer (CRC). We also aim to dissect the tumor-suppressive effects of TRIF/TLR3 signaling with the help of genetically engineered mouse models. The translational relevance of the preclinical findings will be evaluated using two large, independent human CRC cohorts.
DFG Programme Collaborative Research Centres
Subproject of SFB 1371:  Microbiome Signatures -- Functional Relevance in the Digestive Tract
Applicant Institution Technische Universität München (TUM)
Project Heads Professor Dr. Klaus-Peter Janssen; Professor Dr. Sebastian Zeissig