Microbiota- and TLR-dependent regulation of intestinal tumor development
(P10)
Subject Area
Gastroenterology
Term
from 2019 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 395357507
Microbial factors can either promote or inhibit intestinal tumor development through activation of various TLR (toll-like-receptor)-dependent pathways. Here we aim to analyze whether specific microbial taxa are responsible for promoting tumor compared to tumor-suppressive effects in mouse models of colorectal cancer (CRC). We also aim to dissect the tumor-suppressive effects of TRIF/TLR3 signaling with the help of genetically engineered mouse models. The translational relevance of the preclinical findings will be evaluated using two large, independent human CRC cohorts.
DFG Programme
Collaborative Research Centres
