Defining intestinal microbiota orchestrating immune tolerance to intervene with allergic reactions to food and beyond (P06)

• Subject Area: Dermatology ; Gastroenterology
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 395357507

The aim of this tandem is to create minimal consortia with which food allergy can be prevented or treated. We could already show that susceptibility to food allergy mediated by exposure to alpha-gal is efficiently modulated by different microbiota compositions. In the second funding phase, we will further characterize our identified bacteria and further select those capable to induce resilience to alpha-gal allergy. We will establish murine and human minimal consortia to induce this resilience in germfree mice. Since the pig more closely resembles humans in terms of physiology and diet, we will establish FMT in pigs and finally investigate the therapeutic potential of the human resilience associated minimal consortia as `bacterial therapeutics’ to prevent or treat food allergies and even allergic inflammation in general.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1371: Microbiome Signatures -- Functional Relevance in the Digestive Tract
• Applicant Institution: Technische Universität München (TUM)
• Project Heads: Professor Dr. Tilo Biedermann; Dr. Konrad Fischer; Professorin Dr. Angelika Schnieke, until 12/2022