Renoprotective role of Angiotensin-(1–7)
(B06)
Subject Area
Nephrology
Endocrinology, Diabetology, Metabolism
Term
from 2019 to 2022
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 394046635
The ACE2/Angiotensin (Ang)-(1-7)/Mas axis of the renin-angiotensin system may play an important role in renal diseases. Therefore, we will study the expression of components of this axis and the signaling pathways of Ang-(1-7) and Mas in different renal cell types. Moreover, we will generate transgenic animal models with targeted dysregulation of this axis in defined renal cell types. We will expose these animals to renal disease models and will analyse renal function and damage using state-of-the-art physiological, histological and imaging technologies. As a first step into translation of these results, we will use newly developed orally available Mas agonists for the preclinical evaluation of therapies for renal diseases based on the ACE2/Ang-(1-7)/Mas axis.
DFG Programme
Collaborative Research Centres
